疾病学术中心 > CHANGE网络教育中心 > 文献服务
网络课堂
网络课堂
网络课堂
网络课堂

网络课堂

change网络课堂

CHANGE网络课堂共有十个课件。均为国内知名专家撰写。 课程包括:总论课程(必学)和分论课程。

学习第一次通过80%的答题或者第一次学习通过低于80%但学习第二次通过90%的答题的会员, 就有机会获得由辉瑞制药有限公司提供的奖品。每月发放100份,全年发放1000份。 …… >> 进入网络课堂

热点讨论
热点讨论
热点讨论
热点讨论

热点讨论

热点讨论

您在临床工作中一定管理过炎症性肠病(IBD)吧!IBD包括克罗恩病与溃疡性结肠炎,传统的治疗方法对多数患者有效。然而随着近年来发病率的逐渐增高,病例数的不断增加,一些常规药物如SASP、美沙拉嗪、奥沙拉嗪等治疗效果差甚至无效的患者亦逐渐增多…… >> 详细

冒险天地
冒险天地
冒险天地
冒险天地

冒险天地

冒险天地

[神经内科]1998年.Methylprednisolone reduces adhesion molecules in blood and cerebrospinal fluid in patients with MS

 

OBJECTIVE: To analyze the expression of adhesion molecules on mononuclear cells from blood and CSF of patients with exacerbations of MS before and after megadose IV methylprednisolone (MP).

BACKGROUND: Adhesion molecules regulate transmigration of lymphocytes and monocytes/macrophages to the CNS and have an important role in the pathogenesis of MS.

METHODS: The expression of very late activation antigen 4 (VLA-4) and vascular cell adhesion molecule 1, lymphocyte function-associated antigen 1 (LFA-1), and intercellular adhesion molecule 1 (ICAM-1) was analyzed immunocytologically on lymphocytes and monocytes from blood and CSF of 23 patients and 11 healthy control subjects. The results were correlated with the Expanded Disability Status Scale and in half of the patients with the number of T2-weighted MS plaques and brain atrophy analyzed by MRI.

RESULTS: After treatment, the mean proportions of VLA-4, LFA-1, and ICAM-1 on blood lymphocytes (p < 0.0003, p < 0.00001, p < 0.01) and monocytes (p < 0.0001, p < 0.0002, p < 0.007) of 23 patients decreased. The expression of these adhesion proteins was also diminished on CSF leukocytes. However, even after treatment, the levels of VLA-4 and LFA-1 on lymphocytes from blood of MS patients remained higher than in the control subjects. The level of VLA-4 and LFA-1 on blood lymphocytes (r=0.67, p=0.023) and VLA- 4 on monocytes (r=0.61, p=0.047) correlated with the number of T2- weighted lesions.

CONCLUSIONS: Megadose MP may suppress brain inflammation by reducing the expression of adhesion molecules on mononuclear cells from blood and CSF of MS patients. The inhibition of cellular trafficking in MS by MP offers an important means of altering the autoimmune response in MS.

 

     若您对此文有进一步需求,请与好医生医学策划庄建林联系。 邮箱:zhuangjianlin@mail.haoyisheng.com

北京健康在线技术开发有限公司

© 2000-2008 版权所有 京ICP证040426号 卫网审字[2001]第005号

Tel: 8008105790 服务信箱:webmaster@haoyisheng.com.cn