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您在临床工作中一定管理过炎症性肠病(IBD)吧!IBD包括克罗恩病与溃疡性结肠炎,传统的治疗方法对多数患者有效。然而随着近年来发病率的逐渐增高,病例数的不断增加,一些常规药物如SASP、美沙拉嗪、奥沙拉嗪等治疗效果差甚至无效的患者亦逐渐增多…… >> 详细

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[神经内科]1990年.Role of arachidonic acid metabolism on ischemic brain edema and metabolism

 

Arachidonic acid is liberated from damaged cell membranes during ischemia and is the source of vasoactive prostanoids. In this study, specific drugs that influence AA metabolism were investigated for their effects on brain edema and energy metabolites during ischemia. The agents tested were: methylprednisolone (phospholipase A2 inhibition), indomethacin (cyclooxygenase inhibitor), trapidil (TXA2 synthetase inhibitor), and OP-41483 (prostacyclin derivative). Cerebral ischemia was produced using bilateral common carotid artery occlusion in spontaneously hypertensive rats. Brain water content and concentrations of ATP, pyruvate, and lactate were determined 3 hr after occlusion. Compared with its vehicle, methylprednisolone significantly reduced water content and lactate concentration and maintained high levels of ATP. Indomethacin had no effect on brain water content nor metabolite levels. Trapidil decreased water content and lactate levels and increased levels of ATP and pyruvate. OP-41483 had no effect on water content and lactate, but maintained ATP and pyruvate at high levels. These results indicate that some of the AA metabolites may play an important role in the development of brain edema and in the impairment of energy metabolism.

 

 

 

 

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