疾病学术中心 > CHANGE网络教育中心 > 文献服务
网络课堂
网络课堂
网络课堂
网络课堂

网络课堂

change网络课堂

CHANGE网络课堂共有十个课件。均为国内知名专家撰写。 课程包括:总论课程(必学)和分论课程。

学习第一次通过80%的答题或者第一次学习通过低于80%但学习第二次通过90%的答题的会员, 就有机会获得由辉瑞制药有限公司提供的奖品。每月发放100份,全年发放1000份。 …… >> 进入网络课堂

热点讨论
热点讨论
热点讨论
热点讨论

热点讨论

热点讨论

您在临床工作中一定管理过炎症性肠病(IBD)吧!IBD包括克罗恩病与溃疡性结肠炎,传统的治疗方法对多数患者有效。然而随着近年来发病率的逐渐增高,病例数的不断增加,一些常规药物如SASP、美沙拉嗪、奥沙拉嗪等治疗效果差甚至无效的患者亦逐渐增多…… >> 详细

冒险天地
冒险天地
冒险天地
冒险天地

冒险天地

冒险天地

[神经内科]1983年.Effects of methylprednisolone on tumor-induced brain edema

 

Local cerebral blood flow (LCBF), local cerebral glucose utilization (LCGU) and capillary permeability were studied in rats with tumor-induced brain edema. Moreover, effects of methylprednisolone on these physiological parameters were studied to analyse a possible role of steroid on treatment of peritumoral brain edema. A cubic millimeter pellet of Walker 256 tumor was transplanted to the left sensorimotor cortex of the rat brain. Animals were randomly divided into two groups. One group was treated with methylprednisolone (15 mg/kg/day) for 5 days starting at 5 days after tumor inoculation, and the other group received no treatment. These rats were used for autoradiographic study at 10 days after tumor inoculation. Local CBF, LCGU and capillary permeability were measured with 14C-iodoantipyrine, 14C-deoxyglucose and 14C-alphaaminoisobutyric acid, respectively. In the untreated group, LCBF and LCGU were widely depressed in the cortex and deep structures of the hemisphere ipsilateral to the tumor. Of the methylprednisolone treated animals LCBF and LCGU were significantly better than that of untreated animals. Capillary permeability of the untreated animals were highly increased in the viable part of the tumor. Some increase was also noted in the peripheral edge of the tumor and adjacent brain. In the methylprednisolone treated groups, capillary permeability was significantly lower than that in untreated group. The data suggest that methylprednisolone decreases capillary permeability in the viable part of the tumor.

 

 

 

 

 

     若您对此文有进一步需求,请与好医生医学策划庄建林联系。 邮箱:zhuangjianlin@mail.haoyisheng.com

北京健康在线技术开发有限公司

© 2000-2008 版权所有 京ICP证040426号 卫网审字[2001]第005号

Tel: 8008105790 服务信箱:webmaster@haoyisheng.com.cn